Monday, September 27, 2010

Sorority Initiation Practices

The measurement of apolipoproteins as the best parameter for estimate the cardiovascular risk

Da some time I started working for apolipoproteins, which are the protein moiety of lipoproteins, the most common are the VLDL (Very high density lipoproteins), LDL (low density lipoproteins , also known as "bad" cholesterol ) and HDL ( High density lipoprotein, the "good" cholesterol ). More and more data are accumulating in favor of the use of apolipoproteins in routine tests to investigate the presence of cardiovascular risk factors. Traditionally, in fact, a good indicator of risk is the measure of total cholesterol divided by HDL cholesterol ("good"): a ratio greater than 4.5 is considered synonymous with increased cardiovascular risk. The assessment instead of the apolipoproteins, especially dell'ApoB (in the "bad" cholesterol) and dell'ApoA-I (this nell'HDL) would seem to be associated with a higher probability of detecting individuals at risk of cardiovascular disease, compared with more analysis traditional. The ratio ApoB / ApoA-I seems to be a more accurate predictor, since a high value of this parameter is strongly linked to cardiovascular risk not only generic, but it seems to be even a valid predictor of fatal infarction, which is not however, if it occurs cholesterol tout court. Other clinical manifestations associated with high levels of the ratio ApoB / ApoA-I include obesity and metabolic syndrome. In addition, the measurement of apolipoproteins may also be made in the subject is not fasting, that makes things better. I am currently considering which foods are strongly associated with high levels of this relationship: I'll keep you updated on my findings in the Swedish post future! For those wishing to read a good review on the subject, I recommend: Walldius G and Jungner I (2006), J. Int Med 259: 493-519.

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